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Obesity can worsen low-grade inflammation, which can, in turn, lead to neuroendocrine dysfunction

Food intake triggers insulin release, which blunts the growth hormone response

Outcomes and follow-up The primary outcome was the composite of HFE and all-cause mortality

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They are recognized by PRRs [e.g., lipopolysaccharide (LPS) from Gram-negative bacteria (recognized by TLR4), flagellin (TLR5), lipoteichoic acid and peptidoglycan from Gram-positive bacteria (TLR2), viral nucleic acids, like double-stranded RNA (TLR3) and unmethylated CpG DNA (TLR9)], triggering the innate immune response