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Although redressing the BA composition has proved to be beneficial in mouse models, it was unlikely to translate to human pathophysiology, as changes in BA composition in mice hardly reflect similar changes in BA profiles in humans due to the differences in BA composition 41

So rather than forcing an increase, it supports the bodys natural process.

Peptide Epigenetics Khavinson et al

The greater reactivity of dithiols compared to monothiols with respect to reactions with dithiolethiones was determined to be due to an intrinsic enhanced reactivity of specific biological dithiol targets [60]

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