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MTX treatment caused a prominent dilatation of tubules and degeneration in tubular cells, marked vascular and glomerular congestion, dilatation in Bowmans space and inflammatory cell infiltration in the interstitium (Fig

Endothelial function and dysfunction: Testing and clinical relevance

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Accumulation of senescent cells in tissues has been associated with age-related functional decline, chronic inflammation, and impaired tissue regeneration

In contrast, it must be noted that microbiota composition impacts the hydroxylation of calcifediol by CYP27B1, as shown in germ-free mice exhibiting high fibroblast growth factor 23 (FGF23)-levels which correlate to decreased cholecalciferol-metabolization rates [169]