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Abstract Background: Although oxidative stress is known to contribute to cancer, and endogenous and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative stress-induced DNA damage, antioxidants have also been reported to show negative effects on tumor formation, necessitating characterization of the causal associations between antioxidants and cancer risk

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The hairy appearance is due to elongation of keratinized filiform papillae that may show various colors from yellow-brown to black depending on extrinsic factors, ie, tobacco, coffee, tea, food, and intrinsic factors, ie, chromogenic organisms in the normal flora (19)

Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress

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