[2] [3] They work by mimicking the action of a naturally occurring hormone called GLP-1, which is released from the intestine in response to food intake
The synaptic hypothesis of enteroendocrine communication posits that axons within the intestinal lamina propria, presumably of vagal afferent origin, occasionally establish synapse-like connections with the neuropod of enteroendocrine cells including GLP-1 cells 38,39,59
Push hard on one pathway and it quietly compensates through another, which is why we chase a goal like younger skin through several routes at once, like antioxidants, sleep, protein, training, and daily sun protection
However, these therapies are commonly accompanied by adverse gastrointestinal and cardiovascular effects that limit their use [12]
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