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CPE CBRND Press Release Oct 4, 2024 (US Military Website)

Activates AMPK : A cellular energy sensor that improves metabolism and reduces oxidative stress

[41] Dapagliflozin is a C-aryl glucoside discovered similarly through testing different R substituent groups and finding an EC50 of 1.1 nM to h SGLT2 and 1390 nM to h SGLT1, showing approximately 1200-fold selectivity for SGLT2 than SGLT1 in comparison to Canagliflozin having a 260-fold selectivity (Table 1)

This indicates that the biased agonism properties of tirzepatide, which preferentially activates specific signaling pathways, enhance its ability to stimulate insulin secretion [17, 18]

Dubois, V., Eeckhoute, J., Lefebvre, P