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IL-6 mediates olfactory dysfunction in a mouse model of allergic rhinitis

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5-Amino-1MQ is a small-molecule compound and selective inhibitor of NNMT (Nicotinamide N-methyltransferase), an enzyme involved in regulating NAD+ metabolism and one-carbon pathway signalling

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These mechanisms include changes in microbial composition, immune activation, vagus nerve signaling, and the production of specific microbial neuroactive metabolites (197)