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patients should be counseled to report symptoms such as neck mass, dysphagia, or persistent hoarseness Contraindication : Personal or family history of MTC or MEN2 Gallbladder disease : Tirzepatide may increase risk of gallstones and cholecystitis Acute kidney injury : Dehydration from gastrointestinal adverse effects may impair renal function Pancreatitis : Patients should be counseled to report severe, persistent abdominal pain Niacin-specific safety concerns: Hepatotoxicity : Baseline liver function tests and monitoring during dose titration and periodically thereafter are recommended
Supplementary Materials Data Availability Statement All the relevant data are available from the corresponding authors upon reasonable request.
Contact your GP or prescribing clinician if you experience: Persistent or worsening fatigue that interferes with daily activities and does not improve with adequate rest Significant breathlessness during normal activities or at rest Chest pain or palpitations these require same-day assessment Severe or persistent dizziness , particularly if associated with fainting episodes Marked pallor noticed by yourself or others Unusual food cravings (pica) or restless legs syndrome Difficulty concentrating or cognitive changes affecting work or daily function Heavy menstrual bleeding or any unexplained bleeding Signs of gastrointestinal bleeding black or tarry stools, persistent change in bowel habit, unintentional weight loss beyond expected with Wegovy, or difficulty swallowing Seek urgent medical attention (call 999 or attend A&E) if you develop: Severe chest pain or pressure Sudden severe breathlessness Loss of consciousness or near-fainting Rapid heart rate with chest discomfort These symptoms may indicate severe anaemia or other serious conditions requiring immediate assessment
But he said the company wants to work with the administration to provide more access for patients
