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Kao et al., 2018)

* Randomized, crossover, single-dose study in 17 healthy volunteers (Cross Research SA, CRO-PK-16-310, 2017) Enriched with Purple Blend Timeless Essentials For Your Daily Ritual

You can see how low a dose this is

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These additional groups are mainly responsible for reactions to sulfonamide antimicrobials rather than the sulfonamide functional group