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Although we are still sorting out all the answers to this complex question, one clear explanation can be found in the numerous intersecting cell signaling pathways that mediate inflammation, immunity, and tissue repair processes

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Growth hormone secretagogues and related signals can raise growth hormone levels and may shift body composition toward more lean muscle mass and less body fat in some contexts

These microbial-derived signals activate hepatic immune pathways, including toll-like receptor-mediated responses, thereby promoting inflammation, hepatocellular injury, and fibrogenesis