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POTENTIAL MECHANISMS UNDERLYING THE DECLINE IN GH SECRETION WITH AGE Three hypothalamic factors regulate GH secretion: somatostatin (Somatotropin Release-Inhibiting Factor, SRIF), growth hormone-releasing hormone (GHRH), and ghrelin (11) (Figure 2)

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It is also reported that Zn toxicity may involve inhibition of NADPH oxidase, and GSH synthesis, which may lead to increased H 2 O 2 and O 2 accumulation (Jin et al

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commonly called glutathione reductase) and thioredoxin reductases are reduced