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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. In semaglutides extension, about two-thirds returned within one year. The pattern reflects removal of appetite suppression after major weight loss

It is important to note that if you're prescribed Ozempic, complete the entire course of the GLP-1 agonist unless your doctor specifically tells you to stop

However, a growing body of clinical data can help address this clinical question

By week three, most patients report that nausea has faded to occasional mild queasiness or disappears entirely, while appetite suppression remains strong and consistent

Generally, adults with a BMI of 30 or higher, or 27 or higher with a weight-related condition like high blood pressure or type 2 diabetes