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Thus, these data indicate that functional Complex II and GPDH are sufficient for ROS production and subsequent induction of regulated cell death induced by supraphysiologic increases in the mitochondrial Q pool

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GPX8 also plays an important role in regulating Ca2+ in the endoplasmic reticulum (13)

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𝐋𝐚𝐭𝐞𝐬𝐭 𝐩𝐨𝐬𝐢𝐭𝐢𝐨𝐧 𝐨𝐟 𝐃𝐏𝐏-𝟒 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 (𝐞.𝐠., 𝐬𝐢𝐭𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐬𝐚𝐱𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐥𝐢𝐧𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐚𝐥𝐨𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐯𝐢𝐥𝐝𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧) 𝐢𝐧 𝐭𝐡𝐞 𝟐𝟎𝟐𝟓 𝐀𝐃𝐀 𝐒𝐭𝐚𝐧𝐝𝐚𝐫𝐝𝐬 𝐨𝐟

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