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Metalloproteinase regulation studies document MMP1 and MMP2 gene expression increases at 0.01 nM with TIMP1 increases at all tested concentrations (0.01-100 nM)

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38 This pain commonly presents as spontaneous burning sensations in the feet, and patients may also report positive sensory symptoms such as brush-evoked allodynia (pain from normally non-painful stimuli) and paresthesias, which are often accompanied by sensory loss, leading patients to describe the paradox of their feet being continuously painful yet insensate to touch

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The LMMs were adjusted for sex, height, BMI score (age-based BMI expressed as standard deviation score [BMI-SDS]), study centre and individual variation