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This Review describes the mechanisms of action of antioxidants synthesized in vivo, antioxidants derived from the human diet and synthetic antioxidants developed as therapeutic agents, with a focus on the gaps in our current knowledge and the approaches needed to close them

10.1007/s13668-022-00441-0 348

JiangXAndjelkovicA V.ZhuLYangTBennettMVLChenJet al

NAC is the supplement form of cysteinea non-essential amino acid that helps create the important antioxidant glutathioneand its exceptionally versatile

Thiol redox status regulate MPT and enhanced ROS generation can target critical cysteine residues in cyclophilin D, implying that mGSH depletion would favor MPT via redox pathways targeting MPT components