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A phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors

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In the fourth step, the ternary complex decomposes to yield the free oxidized cytochrome, the oxidized form of the drug, and water Hydrolytic reactions involve substrates that contain ester linkages

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(4) The study must include a certain dosage of antioxidant enzymes (e.g., SOD, catalase, glutathione peroxidase, glutathione reductase, etc.) and a certain dosage of oxidative damage markers [e.g., malondialdehyde (MDA), etc.]