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Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: potential role of metal dyshomeostasis in Crohns disease

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Patients underwent a 9 week run-in period (3-week forced dose escalation followed by a 6-week dose maintenance phase) with rosiglitazone (starting at 4 mg and increasing to 8 mg/day within 2 weeks) and metformin (starting at 500 mg with increasing weekly increments of 500 mg to a final dose of 2,000 mg/day)

While these symptoms are rarely due to thyroid cancer, they warrant prompt evaluation