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Understanding GLP-1 Therapy and Weight Loss Plateaus GLP-1 receptor agonists (hormone-mimicking medications like semaglutide) work by increasing feelings of fullness, slowing stomach emptying, and reducing appetite

By mimicking a hormone in the body by GLP-1 receptor agonist, Semaglutide increases insulin secretion while slowing down how fast your stomach empties food

Nausea, diarrhea, vomiting, and upset stomach are commonly reported with either medication, and they carry similar risks and warnings

GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids