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Chinese medicines are shown as laxative and lubricating agents by stimulating Cl secretion and/or inhibiting sodium (Na+) absorption across the colonic epithelium.38 Flavonoids, one of the secondary metabolites present inGAAE,are suggested toactivate a cAMP-dependent cystic fibrosis transmembrane conductance regulator (CFTR).39 The CFTR is found in the apical membrane of epithelial cells40 including the intestine41 and could promote either reabsorption or secretion depending on the anion driving forces.40 The failure of peristalsis to move the luminal content through the colon is the major mechanism underlying constipation

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Once the bodys receptors are saturated, any additional B12 is simply filtered out by the kidneys

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