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GLP-2R+ myofibroblasts in the small intestine and colon contain keratinocyte growth factor (KGF), whereby immunoneutralization of KGF abolishes the trophic effects of GLP-2 treatment in the colon, but not the small intestine in mice (Orskov et al., 2005)

All other efforts ( i + 3 , i + 4 , Aib, etc.), including analogs with staples oriented at the hydrophobic interface, did not provide peptides with comparable activity

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A gene cross-referencing analysis was complicated by the large number of deregulations found in the Dyson et al