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Most peptide evidence comes from animal models, small studies, and mechanistic extrapolation
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The lactylation of histones in immune cells (e.g., macrophages) encourages their transformation into an M2 phenotype to advance tumor proliferation and immune escape [22]
Nauck MA, Quast DR, Wefers J, Meier JJ (2021) GLP-1 receptor agonists in the treatment of type 2 diabetes state-of-the-art
Older oral anti-obesity agents phentermine-topiramate extended release, naltrexone-bupropion, orlistat have smaller mean effects but are often available at far lower cost, sometimes as generics
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