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Gynecologic Oncology

International Journal of Molecular Sciences 23 , 4334 (2022)

Exogenous MG exposure (Figure 4) further revealed two distinct ferroptosis-promoting mechanisms: covalent binding-mediated glutathione depletion, which crippled glutathione peroxidase activity, and suppression of selenoprotein biosynthesis, evidenced by diminished GPX4 and SLC7A11 expression (Figure 5)