The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases
GLP-1 agonists can be valuable for selected patients, particularly those with obesity and metabolic comorbidities, but long-term PCOS care should remain holistic combining metabolic management with mental health support, lifestyle sustainability, reproductive health, and patient education
Quality Assurance & Certifications
Recommended dosing framework CLA: 36g per day, split across meals
The arginate version simplifies this process, allowing researchers to prepare solutions that remain viable for longer, ensuring the dose on day 30 is just as potent as the dose on day 1
