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When monotherapy is not sufficient, sulfonylureas, meglitinides, thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) agonists (liraglutide, exenatide, semaglutide, dulaglutide) or insulin can be combined (171)

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The challenge lies in the pace of glucose reduction rather than the medication itself