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According to the National Academies of Sciences, Engineering, and Medicine (NAP), a safe highest level is called the tolerable upper intake level. Assessment of what amount is too much is based on animal and human studies, published evidence of adverse events, and professional agreement based on a committee of experts
PMC 5390862
Biochemical and preclinical investigations suggest that AOD 9604 affects pathways involved in cellular energy regulation, including cyclic AMP signaling and downstream kinase activation
[7] High-dose methionine may antagonize the therapeutic effect of L-dopa-carbidopa regimens by increasing peripheral methylation of the drug complex, potentially reducing central bioavailability
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