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In this section, we examine how PDCOs are advancing personalized treatment strategies for digestive system cancers, including standard approaches such as chemotherapy, radiotherapy, targeted therapy, and immunotherapy, as well as emerging modalities like microbiome-based interventions and photodynamic therapy

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Notably, an IG-CDR-based peptide designed to disrupt MIF-CD74 signaling has been shown to reduce the accumulation of M-MDSCs in metastatic melanoma lesions [136]

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