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Androgen deficiency can be caused by genetic disorders, medical problems, damage to the testes or pituitary gland, cancer treatment, some types of infection or other diseases

The most clinically significant comparative finding came from the SURMOUNT-5 head-to-head trial in 2024, the first direct comparison between two FDA-approved weight loss medications

This affects vital organelles such as mitochondria, causing alterations in the biophysical properties of the membrane, disrupting the electron transport chain activities, decreased fluidity, and subsequently an energy imbalance