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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

If they whine give them some but tell them they dont need it, its just that they have become dependent upon it

Discontinuing peptide therapy often leads to weight regain

Ultimately, sustainable fat loss still depends on consistent lifestyle habits, balanced nutrition, and regular physical activity