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Aim The aim of the proposed protocol is to compare the effectiveness of orally and intramuscularly administered vitamin B12 in the normalisation of serum vitamin B12 concentrations at 8, 26 and 52 weeks of treatment, in patients aged 65 years with vitamin B12 deficiency treated at primary healthcare centres in the Madrid region, Spain

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In the UK, typical oral doses for dietary deficiency are 50-150 micrograms daily, with higher doses (1000-2000 micrograms) generally reserved for clinical situations under healthcare supervision

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