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However, this systemic insulin resistance creates a unique and devastating problem for the reproductive system, often referred to as the "Ovarian Paradox." While the muscles and peripheral tissues become resistant to insulin, the ovaries remain highly sensitive to it

Both support muscle cell function and recovery

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Findings suggest it modulates extracellular matrix remodeling and fibrosis, in part through transforming growth factor-beta (TGF-?) signaling pathways [7]

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