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Studies show the consuming an excessive amount of vitamin B12 may: Increase the risk of cardiovascular events in people with diabetic nephropathy : A study published in JAMA sought to determine whether B vitamin therapy was able to slow the progression of diabetic nephropathy (kidney damage due to diabetes) and prevent vascular complications

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One 2017 study published in Scientific Reports showed that just 11 days of 5-Amino-1MQ led to measurable improvements in obesity-related biomarkers in mice fed a high-fat diet