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When GLP-1R on -cells is activated, it binds to G proteins, particularly Gs proteins, which increases the intracellular concentration of cAMP (Table 1), contributing to an increase in -cell numbers ( TABLE 1 Mechanism of glucose-lowering action of GLP-1R

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Over time, this can lead to insulin resistance , a precursor to type 2 diabetes

Session 4: Small Group Working Sessions Format: Interactive Working Sessions Around a Roundtable (In-Person Only) In this interactive and collaborative session, in-person attendees will participate in focused discussions on key topics from Day 1, including API characterization challenges, analytical method development, stability strategies, and manufacturing considerations