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People with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2) should not use GLP-1 receptor agonists because of potential tumor risks observed in animal studies

Dinh Tran, MD at Family Health Care What is a B12 injection, and how does it enhance overall health

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

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