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A 2023 JAMA study found that people using GLP-1 drugs had a higher risk of gastroparesis and bowel obstruction compared to those taking bupropion-naltrexone

Research into semaglutide's effects on gut bacteria is ongoing, but early evidence suggests it may increase the proportion of certain bacteria that produce sulfur compounds as a byproduct of fermentation

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A majority of individuals currently taking a GLP-1 for weight loss plan to continue for less than two more years, and 90% of those who had discontinued use were on the medication for less than one year