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Understanding How GLP-1 Medications Work GLP-1 (glucagon-like peptide-1) medications mimic a natural hormone that helps: Regulate blood sugar levels Slow digestion to keep you feeling full longer Reduce appetite and cravings This combination makes it easier to eat less and maintain healthier habits leading to gradual, sustainable weight loss over time

The PPAR// triple agonist lanifibranor (Lani) is currently in clinical phase 3 trials for the treatment of MASH

Rare Risks: Though uncommon, serious complications such as gallbladder issues or pancreatitis can occur

doi: 10.1039/c5ib00158g 211 LiuMBingG

[127] Emerging data from the STEP UP trial, reported in January 2025, tested higher-dose semaglutide at 7.2 mg weekly in obese adults without diabetes, achieving a mean 20.7% weight reduction over 68 weeks, superior to 2.4 mg (15.3%) and placebo (2.6%), with comparable tolerability