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They are located at cellular membranes and transduce signals through G-protein activation ( Estrogens also regulate fetal neural development through the membrane receptor (GPER) ( The GABA(A) receptor is a ligand-gated ion channel regulated by neuroactive steroids ( + -K + -2Cl - cotransporter SLC12A2, promotes the efflux of Cl - , which induces depolarization of the cell membrane, and the subsequent activation of voltage-dependent L-type calcium channels, the activation of PKA kinases, and the expression of cell cycle regulators, lastly inducing proliferation ( P4 plays a crucial role in sustaining pregnancy

Basic Res Cardiol (2016) 111:1