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Tirzepatide activates both the GIP receptor and the GLP-1 receptor, while semaglutide is a GLP-1 agonist only

Impaired glucose tolerance is reversed after the transfer of metformin-altered microbiota to germ-free mice (191)

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During wound healing, MMPs play dual roles: they facilitate tissue debridement and cell migration in early healing phases, while excessive or prolonged MMP activity can impair matrix deposition and delay closure