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Allergic Reactions: Hypersensitivity may occur rarely, producing rash, hives, or mild respiratory discomfort, and prompt medical attention is required for severe or persistent reactions

Mood and Cognitive Changes: B12 is linked to mental health, and deficiency can cause mood swings, memory problems, and even depression

Th22 cells, producing IL-22, are elevated in HT and correlate with anti-thyroglobulin titers, suggesting a role in persistent inflammation (Deertekin et al

There is no established safety data for the combination in any population, so the honest position is that contraindication data does not exist at the combination level

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