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36 Another cause could be a defect in leptin signaling which is related to the suppressor of cytokine signaling 3 (SOCS3) and insulin receptor substrate/phosphatidylinositol 3-kinase (IRS/PI 3-K) signaling pathways

Infants born with neonatal lupus do not have SLE and often neither does the mother, though she has a 20 percent chance of developing lupus later (x)

3.4 Other Neurodegenerative Diseases Huntingtons disease is mainly caused by an autosomal dominant mutation in either of the two copies of the Huntingtin (HTT) gene (Subramaniam et al., 2009