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Meta-analyses have confirmed the benefit of GLP-1 RAs as a class in both secondary and primary prevention of cardiovascular disease, and in reduction of adverse kidney outcomes in people with T2D (Kristiensen et al, 2019

68 IMD therapy for obesity is associated with reduced appetite, temporary food aversion, and changes in taste preferences, especially during the initial stages of therapy

Integrated strategies combining adequate protein intake, resistance exercise, and, where appropriate, emerging pharmacological interventions can help preserve or restore muscle mass

Most patients do not see scale weight loss immediately

From baseline to week 52, mean change in HbA 1c was 14.7 mmol/mol (1.35%-points) in the IcoSema group and 9.88 mmol/mol (0.90%-points) in the semaglutide group