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Post hoc evaluations of the SUSTAIN 6 trial revealed that semaglutide markedly increased the incidence of diabetic retinopathy complications in individuals with a history of retinopathy, especially among insulin users, presumably due to the swift deterioration of pre-existing retinopathy following rapid glycemic control [91]

doi: 10.1016/S0025-7753(14)70107-1 [DOI] [PubMed] [Google Scholar] 221.Osei SP, Akomaning E, Florut TF, et al

Over time, this creates a steady concentration that keeps appetite suppression constant

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However, long-term safety and efficacy data remain limited, and most weight loss programs still rely on GLP-1 monotherapy