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Balanced expression of both is required for healthy tissue remodeling

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In recreational athletes, supraphysiological GH doses are often used either alone or in combination with other doping substances (140), and studies have shown that GH improves anaerobic sprint capacity, but not strength and endurance (141), and increases GH, IGF-I and fasting insulin levels (142, 143) mimicking those seen in acromegaly patients ( Table 1 )

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The coordinates and structure factors have been deposited in the PDB with the accession code 9BN7