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Expression of PPAR is also found in hypothalamic nuclei that govern energy metabolism 24 , and viral-mediated overexpression of hypothalamic PPAR decreases food intake in diet-induced obese (DIO) mice 25

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As a result, investigators have increasingly explored whether GLP-1 therapy might confer protection against colorectal neoplasia, either as a direct biological effect or as a consequence of improved metabolic health

Moreover, disparities in access and coverage, particularly for oral formulations and newer agents, hinder equitable implementation