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The uptick in NAION-related lawsuits follows the publication of a June 2025 study in JAMA Ophthalmology , which found a significant association between semaglutide use and increased risk of optic nerve damage

n = 3 animals analyzed in one experiment

Changes in RBC membrane proteins have been reported in some diseases in which OS is involved, such as chronic kidney disease [34, 35] or chronic obstructive pulmonary disease [36]

Boecking B, Rose M, Brueggemann P, Mazurek B

The brain is also a major site of Mn deposition, with regional concentrations ranging from 0.16 to 0.46 mg/kg, the highest levels found in the globus pallidus and putamen, regions primarily responsible for motor control (Krebs et al., 2014)