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Mechanistically, EV biogenesis depends on the endosomal sorting complexes required for transport machinery and is modulated by stress-responsive pathways, although the precise molecular mechanisms that govern selective packaging of mtDNA into EV remain incompletely understood [92]
The DNA promoter for the membrane-bound protein for COMT (MB-COMT) was found frequently to be hypomethylated in patients with SZ and bipolar disorder versus controls, thus contributing to MB-COMT overexpression and, consequently, increased dopamine degradation in the frontal lobe [122, 123]
Deprey, K
Wang D, Tang L, Zhang Y, Ge G, Jiang X, Mo Y, et al
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