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2022 Dec 29;16:4449-4461

Overall conclusions Cumulative event rates from the primary outcome (fatal chronic heart disease (CHD) or non-fatal myocardial infarction (MI)) of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) treatment group, have demonstrated that because of the superiority of thiazide-type diuretics in preventing one or more major forms of cardiovascular disease (CVD) and their lower cost, they should be the drugs of choice for first-step antihypertensive drug therapy