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10.1016/j.cmet.2005.03.007 255

Diabetologia 61 , 17241733 (2018)

Psychobiotics and the gut-brain axis: advances in metabolite quantification and their implications for mental health

Finally, a third group reflected SGLT2i influences on metabolites, comprising reversal of abnormalities in long-chain fatty acid uptake, provision of ketonaemia as an alternative fuel that augments autophagic flux, improvement in iron homeostasis (increasing the bioreactive Fe pool while lowering ferritin and hepcidin), and mitigation of cytosolic accumulation of harmful glucose and lipid by-products, accompanied by an overall enhancement of mitochondrial oxidative metabolism