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[1] It is investigated for its potential role in nitric oxide pathway modulation, growth factor signaling, and extracellular matrix remodeling
These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005
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Difficulties arising from potential immunogenicity, large molecular weight, need for carriers for their delivery and instability in vivo are well recognized [188]
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