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Risk of bias 10 of 11 studies were judged to be at low risk of bias across all RoB2 [10] domains, including randomisation and allocation (D1), deviations from intervention (D2), missing outcome data (D3), measurement of outcome (D4) and selection of reported results (D5)

Glutathione-responsive nanosystems are engineered to remain stable in circulation but undergo structural changes or drug release specifically in high-GSH tumor cells, improving therapeutic precision and reducing off-target toxicity