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How it works (the simple science)

This seemingly minor structural modification drastically alters the compound's pharmacokinetics and biological capabilities

490 FBXW7, which catalyzes the degradation of the anti-apoptotic protein MCL1, plays a key role in myeloid cells and SLE progression

J Neurol Sci 1997;150(5):S209

TLR4 expression is increased in patients with GERD, triggering an inflammatory response involved in the further development of GERD.TLR4 expression in normal squamous epithelial samples is mainly confined to the basal layer of the squamous epithelium, which routinely may not come into contact with PAMPs expressed by the esophageal microbiota, and reflux increases TLR4 expression (49)